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BPS Pharmacotherapy (Part1 and Part2) Sample Questions:

1. A 47-year-old patient with end-stage renal disease undergoing hemodialysis has an HCT of 23% and exhibits anginal symptoms. Upon further Workup, no evidence of occult bleeding is found.
In addition to antianginal therapy, which of the following is the most appropriate initial treatment for this patient's anemia?

A) Oral iron
B) Iron dextran
C) Two units of PRBCs
D) Subcutaneous erythropoietin

2. A patient presents a first-time prescription for exenatide subcutaneously twice daily. Which of the following information should the pharmacotherapy specialist present during patient counseling?

A) The most common side effect is nausea, which usually decreases over time.
B) The drug should be taken within 60 minutes after eating the morning and evening meals.
C) The drug should be discarded 60 days after first use, even if some remains in the pen.
D) Dose size should be adjusted according to the size of each meal.

3. Which of the following is an example of a sentinel event, as defined by the Joint Commission?

A) Administration of digoxin to the Wrong patient without adverse events
B) Removal of the Wrong breast during surgery
C) Death due to heart failure following discharge against medical advice
D) Death due to overdose of methylphenidate obtained from a brother's prescription

4. A pharmacotherapy specialist is interpreting a published paper describing a randomized controlled, double-bling study that was conducted to evaluate the effects of antihistamines on the failure rate of treatment of otitis media in children. In the study, 250 children received antihistamines and 264 did not. All children received appropriate antibiotic therapy. Treatment failures occurred in four (1.6%) of the children who received antihistamines and in 13 (4.9%) of those who did not. The difference is statistically significant (p<0.05, chi-square). Which of the following statements about these result is appropriate?

A) Knowledge of the rate and severity of adverse event in the study is needed to allow a therapeutic decision.
B) The sample size is inadequate to allow clinical conclusions.
C) Antihistamines should be administered to all children with otitis media who meet study entry criteria.
D) Chi-square is not the appropriate statistical test.

5. Many clinically important adverse drug reactions (ADRs) are detected after the marketing of a drug, rather than during premarketing clinical trials. Of the following, which is the primary reason for this phenomenon?

A) Adverse reactions that are due to drug interactions or drug accumulation in renal insufficiency cannot be studied prospectively during the premarketing phase of clinical evaluation.
B) Too few patients are studied for too short a period of time during premarketing clinical trials.
C) Premarketing studies focus on efficacy rather than on safety; therefore, the study design accounts for the failure to detect ADRs.
D) Pharmaceutical companies prefer to market agents with favorable side-effect profiles, so they focus premarketing studies on efficacy rather than on ADRs.

Solutions: